Fenfluramine, sold under the brand name Fintepla, is a serotonergic medication used for the treatment of seizures associated with Dravet syndrome and Lennox—Gastaut syndrome. Side effects of fenfluramine in people treated for seizures include decreased appetite, somnolence, sedation, lethargy, diarrhea, constipation, abnormal echocardiogram, fatigue, malaise, asthenia, ataxia, balance disorder, gait disturbance, increased blood pressure, drooling, excessive salivation, fever, upper respiratory tract infection, vomiting, appetite loss, weight loss, falls, and status epilepticus. Fenfluramine is indicated for the treatment of seizures associated with Dravet syndrome and Lennox—Gastaut syndrome in people age two and older. The most common adverse reactions in people with seizures include decreased appetite; drowsiness, sedation and lethargy; diarrhea; constipation; abnormal echocardiogram; fatigue or lack of energy; ataxia lack of coordination, balance disorder, gait disturbance trouble with walking ; increased blood pressure; drooling, salivary hypersecretion saliva overproduction ; pyrexia fever ; upper respiratory tract infection; vomiting; decreased weight; risk of falls; and status epilepticus. The distinctive valvular abnormality seen with fenfluramine is a thickening of the leaflet and chordae tendineae.

There is growing interest in the pharmacological treatment of obesity. Before, there were few weight loss medications approved by the FDA. The advent of Glucagon-like peptide-1 receptor agonists GLP-1 receptor agonists, with brand names like Wegovy and Ozempic, has attracted explosive media attention. It is not always easy to determine which medication is right for a particular individual. The market is also rapidly changing, so it is important to keep pace with the available options and their pros and cons. Some weight loss medications have been on the market for many years, and new ones emerge frequently.

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